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functional inactivation of mast cells enhances subcutaneous adipose tissue browning in mice


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Distinct populations of adipogenic and myogenic Myf5 ...- functional inactivation of mast cells enhances subcutaneous adipose tissue browning in mice ,Brown adipose tissues (BAT) are derived from a myogenic factor 5 (Myf5)-expressing cell lineage and white adipose tissues (WAT) predominantly arise from non-Myf5 lineages, although a subpopulation of adipocytes in some WAT depots can be derived from the Myf5 lineage. However, the functional implication of the Myf5- and non-Myf5-lineage cells in WAT is unclear.张弦2021-12-22 · 姓 名:张弦职 称:副教授、硕士生导师职 务:教师所属系:食品科学与工程系邮 箱:zhangxianhfut.edu; zhangxian0426hotmail电 话:个人学习工作简介2021.12 – 至今合肥工业大学食品与生物工程学院,副研究员2016 ...



Dietary cholesterol is essential to mast cell activation ...

Functional Inactivation of Mast Cells Enhances Subcutaneous Adipose Tissue Browning in Mice. ... Adipose tissue mast cells contained and released preformed TNF-α, the cytokine implicated in …

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Adipose tissue NAD+ biosynthesis is required for ... - PNAS

2019-11-6 · Thermogenesis is a fundamental aspect of energy homeostasis. Here, we present evidence that adipose tissue NAD + metabolism is essential for thermogenesis. We found cold exposure activates NAD + biosynthesis mediated by a rate-limiting enzyme, NAMPT, in mouse and human brown adipose tissue (BAT). Loss of NAMPT impairs the gene programs involved …

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Physalis alkekengi Exhibits Antiobesity Effects in Mice ...

2020-3-17 · Physalis alkekengi Exhibits Antiobesity Effects in Mice with Potential of Inducing White Adipose Tissue Browning. is corrected by. Correction to: Physalis alkekengi Exhibits Anti-Obesity Effects in Mice with Potential of Inducing White Adipose Tissue Browning, by Lee et al. Journal of Medicinal Food 2020; 23(3):312–318;DOI: 10.1089/jmf.2019.4625

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肥大细胞在脂肪组织中的生理与病理作用

2020-5-2 · 肥大细胞在脂肪组织中的生理与病理作用 齐睿娟, 高源, 齐云 中国医学科学院&北京协和医学院药用植物研究所,北京 100193 Physiological and pathological …

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Frontiers | Inflammatory Signaling and Brown …

Obesity is characterized by a state of chronic inflammation in adipose tissue mediated by the secretion of a range of inflammatory cytokines. In comparison to WAT, relatively little is known about the inflammatory status of brown adipose …

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The colorful versatility of adipocytes: …

2020-7-3 · Murine brown and white adipose tissue were obtained from lean and diet-induced obese mice kept at room temperature (22 °C) or acclimated to thermoneutrality (30 °C) []. Nonhuman primate brown and white adipose …

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Adipose tissue fibrosis - Microsoft

2018-4-28 · adipose tissue collagens in mice demonstrating that improvement of adipose tissue extracellular matrix composition is one of their beneficial features[23]. The carboxy-terminal domain cleaved from COL-6A3 promotes adipose tissue fibrosis, angiogenesis and inflammation. Increased production of this so called endotrophin in obesity contributes to ...

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Physalis alkekengi Exhibits Antiobesity Effects in Mice ...

2020-3-17 · Physalis alkekengi Exhibits Antiobesity Effects in Mice with Potential of Inducing White Adipose Tissue Browning. is corrected by. Correction to: Physalis alkekengi Exhibits Anti-Obesity Effects in Mice with Potential of Inducing White Adipose Tissue Browning, by Lee et al. Journal of Medicinal Food 2020; 23(3):312–318;DOI: 10.1089/jmf.2019.4625

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A review on the biology and properties of adipose tissue ...

2020-7-9 · Adipose tissue can be divided into white adipose tissue (WAT) and brown adipose tissue (BAT); the percentage of WAT is up to 5 to 50% of body weight including subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT), and the percentage of BAT decreases with age [].Adipose tissue is not only the body’s energy reservoir to insulate against the cold …

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PPARγ activation improves the microenvironment of ...

2021-3-29 · Obesity is linked to elevated cardiovascular risk and adverse cardiac outcomes and may lead to fatal consequences [].Many studies, including ours, have shown that obese populations, regardless of age, have increased arterial stiffening, particularly in the central arteries [2,3,4,5].The stiffness of elastic arteries such as the aorta is an independent predictor of …

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Characterization of Myeloid Cellular ... - Scientific Reports

2020-2-4 · Functional Inactivation of Mast Cells Enhances Subcutaneous Adipose Tissue Browning in Mice. Cell Rep. 28 , 792–803 e794 (2019). CAS …

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Mast Cells in Diabetes and Diabetic Wound Healing - …

2020-10-10 · Mast Cells in Diabetes and Diabetic Wound Healing Jie Dong. Lihong Chen. Ying Zhang. ... Functional inactivation of MCs or inhibition of MC sero-tonin synthesis in subcutaneous adipose tissue promotes adipocyte browning and systemic energy …

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Characterization of Myeloid Cellular Populations in ...

2021-7-27 · Subcutaneous Adipose tissue of Holstein-friesian cows Brbara M. oliveira 1,2, ... reported here may be useful for further studies addressing the function of the described cells. ... genic\beige\fat4\while\functional\inactivation\of\mast\cells\increases\adipocyte\browning\and\thermogenesis5.\

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Obesity-Induced Changes in Adipose Tissue …

2016-5-27 · Neutrophils accumulate rapidly in the adipose tissue after high-fat diet feeding, 81 – 83 and they seem to promote macrophage recruitment and adipose tissue inflammation via neutrophil elastase secretion. 82,83 Similarly, …

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Adipocyte Ceramides Regulate Subcutaneous Adipose …

2016-11-3 · Functional Inactivation of Mast Cells Enhances Subcutaneous Adipose Tissue Browning in Mice. Zhang X, Wang X, Yin H, Zhang L, Feng A, Zhang QX, Lin Y, Bao B, Hernandez LL, Shi GP, Liu J. Cell Rep, 28(3):792-803.e4, 01 Jul 2019 Cited by: 12 articles | PMID: 31315055 | PMCID: PMC6662660

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Stimulation of histamine H4 receptor ... - Physiology

2019-12-6 · Although many studies have shown that histamine and its signaling regulate energy homeostasis through the central nervous system, their roles in adipose tissues remain poorly understood. Here, we identified that the histamine H4 receptor (HrH4) was highly expressed in adipocytes at a level higher than that of the other three receptors (i.e., HrH1, HrH2, and HrH3). …

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The cellular and functional complexity of thermogenic fat ...

2021-3-23 · Adipose tissue was once considered to be merely a passive lipid-storing repository. However, it is now clear that adipose tissue is a metabolically active organ with key roles in …

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刘健 - hfut.edu

2021-3-5 · liujian509hfut.edu. 电 话:. 0551-62901349. 个人学习工作简介. 2009年至今, 合肥工业大学食品与生物工程学院,教授. 2006-2009年,美国哈佛大学医学院,博士后. 2001-2006年,中国科学技术大学,硕-博连读. 1995-2001年,安徽省立医院药剂科,主管药师. 1991-1995年,安徽 ...

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Adipose tissue fibrosis - Microsoft

2018-4-28 · adipose tissue collagens in mice demonstrating that improvement of adipose tissue extracellular matrix composition is one of their beneficial features[23]. The carboxy-terminal domain cleaved from COL-6A3 promotes adipose tissue fibrosis, angiogenesis and inflammation. Increased production of this so called endotrophin in obesity contributes to ...

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Alternatively activated macrophages do not synthesize ...

2017-3-24 · It is reported that the deletion of Th in hematopoietic cells of adult mice neither alters energy expenditure upon cold exposure nor reduces browning in inguinal adipose tissue, and hence, the deletion is not likely to have a direct role in adipocyte metabolism or adaptive thermogenesis. Adaptive thermogenesis is the process of heat generation in response to cold …

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肥大细胞在脂肪组织中的生理与病理作用

2020-5-2 · 肥大细胞在脂肪组织中的生理与病理作用 齐睿娟, 高源, 齐云 中国医学科学院&北京协和医学院药用植物研究所,北京 100193 Physiological and pathological …

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Frontiers | Inflammatory Signaling and Brown …

Obesity is characterized by a state of chronic inflammation in adipose tissue mediated by the secretion of a range of inflammatory cytokines. In comparison to WAT, relatively little is known about the inflammatory status of brown adipose …

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Adipocyte Ceramides Regulate Subcutaneous Adipose …

2016-11-3 · Functional Inactivation of Mast Cells Enhances Subcutaneous Adipose Tissue Browning in Mice. Zhang X, Wang X, Yin H, Zhang L, Feng A, Zhang QX, Lin Y, Bao B, Hernandez LL, Shi GP, Liu J. Cell Rep, 28(3):792-803.e4, 01 Jul 2019 Cited by: 12 articles | PMID: 31315055 | PMCID: PMC6662660

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Guo-Ping SHI | ScD | Brigham and Women's …

2022-2-25 · Dr. Guo-Ping Shi is an Associate Professor of Harvard Medical School and Biochemist of Brigham and Women's Hospital. His group is interested in the roles of cysteinyl cathepsins and inflammatory ...

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