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tissue cells feel and respond to the stiffness of their substrate best


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Tissue cells feel and respond to the stiffness of their ...- tissue cells feel and respond to the stiffness of their substrate best ,2005-11-1 · Tissue cells feel and respond to the stiffness of their substrate. Dennis E Discher School of Engineering and Applied Science and Cell and Molecular Biology Graduate Group, University of Pennsylvania, Philadelphia, PA 19104-6315, USA.Combination of CD34‐positive cell subsets with infarcted ...2014-6-19 · Stem cells are able to feel and respond to the tissue-like matrix stiffness to commit to a relevant lineage. ... behaviour after differentiation induced by deformable matrix with varied stiffness may more closely mimic that of the cells in their normal host tissue. ... regardless of culture substrate stiffness, CD34-positive cell culture system ...



Local contractions regulate E-cadherin rigidity sensing

2022-1-28 · E-cadherin is a major cell-cell adhesion molecule involved in mechanotransduction at cell-cell contacts in tissues. Because epithelial cells respond to rigidity and tension in tissue through E-cadherin, there must be active processes that test and respond to the mechanical properties of these adhesive contacts.

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The influence of substrate stiffness on the behavior and ...

Recent evidence demonstrate that SCs feel and respond to the stiffness of their substrate, and that mechanosensitivity plays key roles in SCs shape, adhesion, migration, differentiation, gene ...

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Discher Lab - University of Pennsylvania

2019-7-24 · Tissue cells feel and respond to the stiffness of their substrate. Science 310:1139-1143 (2005). A. Engler, L. Bacakova, C. Newman, A. Hategan, M. Griffin, and D.E. Discher. ... Cardiomyocytes from late embryos and …

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Tissue Cells Feel and Respond to the Stiffness of their ...

Tissue Cells Feel and Respond to the Stiffness of their Substrate Autores: Yu-li Wang, Dennis E. Discher, Paul Janmey Localización: Science , ISSN 0036-8075, Vol. 310, Nº 5751, 2005 , …

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The Forces of Cancer | The Scientist Magazine®

2016-4-1 · D.E. Discher et al., “Tissue cells feel and respond to the stiffness of their substrate,” Science, 310:1139-43, 2005. J.G. Goetz et al., “Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion …

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Stiffness Sensing by Cells | Physiological Reviews

2020-2-20 · Cells respond to the stiffness of their environment by changing morphology, motility, or proliferation or by altering their differentiation state. ... or osteogenic cell lineages based on matching the substrate stiffness to the target tissue–soft for the brain, stiffer for muscles, and very ... How deeply cells feel: methods for thin gels. J ...

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Riboflavin and collagen: New crosslinking methods to ...

2012-5-1 · Tissue cells feel and respond to the stiffness of their substrate Science (New York, N.Y.) , 310 ( no. 5751 ) ( Nov. 2005 ) , pp. 1139 - 1143 …

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Tissue cells feel and respond to the stiffness of their ...

CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): Normal tissue cells are generally not viable when suspended in a fluid and are therefore said to be anchorage dependent. Such cells must adhere to a solid, but a solid can be as rigid as glass or softer than a baby’s skin. The behavior of some cells on soft materials is characteristic of important …

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Riboflavin and collagen: New crosslinking methods to ...

2012-5-1 · Tissue cells feel and respond to the stiffness of their substrate Science (New York, N.Y.) , 310 ( no. 5751 ) ( Nov. 2005 ) , pp. 1139 - 1143 …

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Discher Lab - University of Pennsylvania

2019-7-24 · Tissue cells feel and respond to the stiffness of their substrate. Science 310:1139-1143 (2005). A. Engler, L. Bacakova, C. Newman, A. Hategan, M. Griffin, and D.E. Discher. ... Cardiomyocytes from late embryos and …

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Sensing rigidity | Nature Materials

2014-5-21 · The stiffness of a cell's underlying substrate also regulates proliferation, cell motility and cell spreading. For the underlying substrate to …

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Readings | Cell-Matrix Mechanics | Mechanical Engineering ...

2020-12-30 · Course readings. TOPICS ADDITIONAL READINGS; Introduction (PDF) Discher, Dennis E., Paul Janmey, et al. "Tissue Cells Feel and Respond to the Stiffness of their Substrate."Science 310, no. 5751 (2005): 1139–43.. Engler, Adam J., Shamik Sen, et al. "Matrix Elasticity Directs Stem Cell Lineage Specification."Cell 126, no. 4 (2006): 677–89.. Tissue …

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respond是什么意思_respond怎么读_respond翻译_用法_发音 ...

How cells respond to interferons. How cells respond to interferons [Review] How cells respond to interferons. Annu Rev Biochem Tissue Cells Feel and Respond to the Stiffness of Their Substrate T cells that cannot respond to TGF-β escape control by CD4+CD25

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Stiffness Sensing by Cells | Physiological Reviews

2020-2-20 · Cells respond to the stiffness of their environment by changing morphology, motility, or proliferation or by altering their differentiation state. ... or osteogenic cell lineages based on matching the substrate stiffness to the target tissue–soft for the brain, stiffer for muscles, and very ... How deeply cells feel: methods for thin gels. J ...

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A novel, visible light-induced, rapidly cross-linkable ...

2014-3-25 · Tissue cells feel and respond to the stiffness of their substrate 14. ... defect (0–4), with 19 being the best score. For immunohistochemistry, the sections were incubated with a …

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Paul A. Janmey, Ph.D. – Institute for Medicine and …

Tissue cells feel and respond to the stiffness of their substrate. Science Nov 18 2005; 310 (5751): 1139-1143. Georges PC, Janmey PA. Cell type-specific response to growth on soft materials. J Appl Physiol (1985) Apr 2005; 98 (4): 1547-1553.

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Home | Cell&Soft

Discher DE et al. Tissue cells feel and respond to the stiffness of their substrate. Science. 2005 310:1139. Bouchonville N et al. AFM mapping of the elastic properties of brain tissue reveals kPa/μm gradients of rigidity. Soft Matter. 2016 12:6232. Mammoto A et al. Mechanosensitive mechanisms in transcriptional regulation.

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Modeling the Impact of Cell Type and Substrate …

2014-6-19 · We propose a mathematical model to suggest a unified explanation behind the observation that some cell types tend to spread more efficiently on stiff substrates and are able to adapt their internal stiffness to the external …

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Tissue cells feel and respond to the stiffness of their ...

Tissue cells really feel and reply to the stiffness of their substrate Regular tissue cells are usually not viable when suspended in a fluid and are subsequently stated to be anchorage dependent. Such cells should adhere to a stable, however a stable might be as inflexible as glass or softer than a child’s pores and skin.

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The influence of substrate stiffness on the behavior and ...

Recent evidence demonstrate that SCs feel and respond to the stiffness of their substrate, and that mechanosensitivity plays key roles in SCs shape, adhesion, migration, differentiation, gene ...

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Tissue Cells Feel and Respond to the Stiffness of their ...

Tissue Cells Feel and Respond to the Stiffness of their Substrate Autores: Yu-li Wang, Dennis E. Discher, Paul Janmey Localización: Science , ISSN 0036-8075, Vol. 310, Nº 5751, 2005 , …

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A novel, visible light-induced, rapidly cross-linkable ...

2014-3-25 · Tissue cells feel and respond to the stiffness of their substrate 14. ... defect (0–4), with 19 being the best score. For immunohistochemistry, the sections were incubated with a …

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A novel, visible light-induced, rapidly cross-linkable ...

2014-3-25 · Tissue cells feel and respond to the stiffness of their substrate 14. ... defect (0–4), with 19 being the best score. For immunohistochemistry, the sections were incubated with a …

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How cells sense extracellular matrix stiffness: a material ...

The mechanical properties of the extracellular matrix (ECM) in which cells reside have emerged as an important regulator of cell fate. While materials based on natural ECM have been used to implicate the role of substrate stiffness for cell fate decisions, it is difficult in these matrices to isolate mechanics from other structural parameters.

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