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connective tissue growth factor a new and important player in the pathogenesis of fibrosis


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The pathogenic role of connective tissue growth factor in ...- connective tissue growth factor a new and important player in the pathogenesis of fibrosis ,2019-7-1 · Connective tissue growth factor (CTGF; also known as CCN2) is a member of the CCN (CYR61-CTGF-NOV) family, which is a group of secreted multifunctional proteins [].CTGF is known to be up-regulated in pathological conditions in regions of severe injury including fibrotic disorders, various cancers, and arthritis.Connective tissue growth factor: a new and important ...2002-4-1 · Connective tissue growth factor: a new and important player in the pathogenesis of fibrosis. Andrew Leask Centre for Rheumatology, Department of Medicine, Royal Free and University College Medical School, Royal Free Campus, Rowland Hill St., London NW3 2PF, UK.



Pathogenesis of systemic sclerosis (scleroderma) - UpToDate

2021-2-16 · Leask A, Holmes A, Abraham DJ. Connective tissue growth factor: a new and important player in the pathogenesis of fibrosis. Curr Rheumatol Rep 2002; 4:136. Dziadzio M, Usinger W, Leask A, et al. N-terminal connective tissue growth factor is a marker of the fibrotic phenotype in scleroderma. QJM 2005; 98:485.

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Connective tissue growth factor/IGF-binding protein ...

2002-4-1 · Connective tissue growth factor: a new and important player in the pathogenesis of fibrosis. Leask A, Holmes A, Abraham DJ. Curr Rheumatol Rep, 4(2):136-142, 01 Apr 2002 Cited by 111 articles | PMID: 11890879. Review

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TGF-β signaling in vascular fibrosis | Cardiovascular ...

Connective tissue growth factor (CTGF) has recently been described as a novel profibrotic factor that mediates some TGF-β responses, including apoptosis and fibrosis . In vivo, blockade of CTGF synthesis or activity reduces TGF-β-induced collagen synthesis. Data suggests that CTGF and TGF-β synergize to promote chronic fibrosis.

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Role of connective tissue growth factor in ... - Physiology

2002-5-1 · Expression of transforming growth factor (TGF)-β1, connective tissue growth factor (CTGF), and fibronectin mRNA in the kidney after unilateral ureteral obstruction (UUO) in rats. Forty micrograms of total RNA from the whole kidney in each lane were electrophoresed and hybridized with rat TGF-β1, CTGF, and fibronectin cDNA probes.

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TGF-β signaling in vascular fibrosis | Cardiovascular ...

Connective tissue growth factor (CTGF) has recently been described as a novel profibrotic factor that mediates some TGF-β responses, including apoptosis and fibrosis . In vivo, blockade of CTGF synthesis or activity reduces TGF-β-induced collagen synthesis. Data suggests that CTGF and TGF-β synergize to promote chronic fibrosis.

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(PDF) Connective tissue growth factor: Just …

Human connective tissue growth factor (hCTGF) is a novel cysteine-rich, secreted polypeptide. hCTGF is implicated in connective tissue formation, which may play an important role in atherosclerosis.

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Connective Tissue Growth Factor in Patients With ...

2021-9-9 · Connective tissue growth factor (CTGF) is a polypeptide that has been shown to be overexpressed in various fibrotic disorders, suggesting its involvement in scarring. After the development of choroidal neovascularization, subretinal fibrosis may occur and result in permanent reduction of vision.

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Differential expression of connective tissue growth factor ...

2019-1-21 · To determine the levels of connective tissue growth factor (CTGF) and hepatocyte growth factor (HGF) in the vitreous of patients with high myopia, in comparison with those with a vitreomacular interface disease (VMID). Patients with either high myopia (high myopia group) or a VMID (VMID group) were included in this study. Each of the two groups were further …

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Transforming growth factor-β1/Smad/connective tissue ...

Introduction: Osteoradionecrosis (ORN) of the mandible is a serious complication following radiation therapy for malignancies of the head and neck. Radiation-induced fibrosis (RIF) is a new theory that accounts for the damage to normal tissues after radiotherapy, and the radiation-induced fibroatrophic mechanism includes the free-radical formation, endothelial dysfunction, …

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(PDF) Growth Factors and Connective Tissue Homeostasis …

Connective tissue growth factor (CTGF) is another Growth Factors and Connective Tissue Homeostasis in Periodontal Disease 57 important mediator of tissue remodelling which stimulates fibroblasts to produce extracellular matrix constituents, so its expression correlates positively with the degree of gingival fibrosis (Heng et al., 2006; Trackman ...

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Connective tissue growth factor causes EMT-like cell fate ...

2013-5-15 · Summary. Connective tissue growth factor (CTGF) plays an important role in the pathogenesis of chronic fibrotic diseases. However, the mechanism by which paracrine effects of CTGF control the cell fate of neighboring epithelial cells is not known. In this study, we investigated the paracrine effects of CTGF overexpressed in fibroblasts of Col1a2-CTGF …

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Connective tissue growth factor: A new and important ...

2002-5-24 · Connective tissue growth factor: A new and important player in the pathogenesis of fibrosis Connective tissue growth factor: A new and important player in the pathogenesis of fibrosis Leask, Andrew; Holmes, Alan; Abraham, David 2002-05-24 00:00:00 Connective tissue fibrosis is the final common pathogenic process for almost all forms of chronic tissue injury.

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Leask A, Holmes A & Abraham DJ. Connective tissue …

Request PDF | Leask A, Holmes A & Abraham DJ. Connective tissue growth factor: A new and important player in the pathogenesis of fibrosis. Curr Rheumatol Rep4: 136-142 | Connective tissue fibrosis ...

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Regulation of connective tissue growth factor gene ...

2017-10-13 · Connective tissue growth factor: A new and important player in the pathogenesis of fibrosis Current Rheumatology Reports, Vol. 4, No. 2 Transforming Growth Factor β Stimulates Fibroblast–Collagen Matrix Contraction by Different Mechanisms in Mechanically Loaded and Unloaded Matrices

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Novel growth factors involved in the pathogenesis of ... - Eye

2002-7-10 · Aims To determine whether hepatocyte growth factor (HGF) and connective tissue growth factor (CTGF) are expressed in human specimens of proliferative vitreoretinopathy (PVR) and to propose a model ...

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Connective Tissue Growth Factor Is Crucial to Inducing a ...

2021-10-6 · The pathogenesis of PF involves a multitude of factors mediating crosstalk between various tissue components. Some factors, such as transforming growth factor β, are recognized as key elements in the process, whereas the role of others, such as connective tissue growth factor (CTGF), is unclear.

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Growth Factors and Connective Tissue Homeostasis in ...

2018-9-25 · Growth Factors and Connective Tissue Homeostasis in Periodontal Disease 57 important mediator of tissue remodelling which stimulates fibroblasts to produce extracellular matrix constituents, so its expression correlates positively with the degree of gingival fibrosis (Heng et al., 2006; Trackman & Kantarci, 2004). Local conditions favour

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Differential expression of connective tissue growth factor ...

2019-1-21 · To determine the levels of connective tissue growth factor (CTGF) and hepatocyte growth factor (HGF) in the vitreous of patients with high myopia, in comparison with those with a vitreomacular interface disease (VMID). Patients with either high myopia (high myopia group) or a VMID (VMID group) were included in this study. Each of the two groups were further …

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Connective tissue growth factor is correlated with ...

2019-8-21 · Connective tissue growth factor (CTGF) is a member of the CCN (CTGF/Cyr61/Nov) family and is an important player in the pathogenesis of fibrotic disorders. CTGF is increased in human PD effluents ...

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Sustained Smad2 Phosphorylation Is Required for ...

2021-10-6 · Connective tissue growth factor: a new and important player in the pathogenesis of fibrosis. Curr Rheumatol Rep 2002 ;4: 136 – 142 . Crossref , Medline , Google Scholar

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Transforming growth factor-β1/Smad/connective tissue ...

Introduction: Osteoradionecrosis (ORN) of the mandible is a serious complication following radiation therapy for malignancies of the head and neck. Radiation-induced fibrosis (RIF) is a new theory that accounts for the damage to normal tissues after radiotherapy, and the radiation-induced fibroatrophic mechanism includes the free-radical formation, endothelial dysfunction, …

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Connective tissue growth factor (CCN2, CTGF) and organ ...

2009-10-2 · Leask A, Holmes A, Abraham DJ (2002) Connective tissue growth factor: a new and important player in the pathogenesis of fibrosis. Curr …

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Connective tissue growth factor: a novel regulator of ...

1998-8-1 · Due to the potent effect of connective tissue growth factor (CTGF) on fibroblast proliferation and connective tissue deposition we speculated about a possible role of this mitogen in IBD. Here we demonstrate a strikingly increased expression of CTGF mRNA in surgical specimens of patients suffering from two forms of IBD, Crohn's disease and ...

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Effects of Connective Tissue Growth Factor and Collagen ...

2007-4-1 · To investigate the effects of connective tissue growth factor (CTGF) and collagen type I (COL-l) on the pathogenesis of scleroderma and explore the re…

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